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DNA nanotechnology and supramolecular chemistry in biomedical therapy applications

Cail, Peter James (2018)
Ph.D. thesis, University of Birmingham.

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Abstract

The overall aim of this thesis is to investigate the combination of supramolecular cylinders with DNA nanotechnology and assess any effects that can occur through binding and any applications this could have in biomedical therapy applications. From this base it is hoped that insight can be gained as to whether supramolecular chemistry can be used to create DNA nano-machines, capable of triggered release of cargo. The thesis begins with a review of DNA discovery, structure and binding by small molecules, followed by a review of the field of DNA nanotechnology. By expanding on the field of DNA nanotechnology recognition, chapters 2 and 3 will highlight the advantages of supramolecular chemistry when combined with DNA nanotechnology in both nano-machines and inside cell systems with a focus on DNA tetrahedral nanostructures. Chapter 4 researches the photocleavage capabilities of a ruthenium cylinder and the possibilities of selective release and photodynamic therapy using a DNA tetrahedron. Chapter 5 illustrates a new class of anti-viral agents capable of structure recognition regardless of RNA sequence. The chapter focuses on the inhibition of binding between the TAR RNA and ADP-1 peptide found in the HIV-1 virus.

Type of Work:Ph.D. thesis.
Supervisor(s):Hannon, Michael J.
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Subjects:QD Chemistry
QR Microbiology
Institution:University of Birmingham
ID Code:8424
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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