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Developing biomaterials through enhancing organic/inorganic interfaces

Hughes, Erik Andreas Bjørnstad (2018)
Eng.D. thesis, University of Birmingham.

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Abstract

The socioeconomic demand for biomaterials has never been greater. Formulation at the organic/inorganic interface of materials has enabled the conception of several biomaterial systems for bone healing. In Chapter 2, a poly( ether ether ketone) (PEEK) and calcium sulphate (CS) composite is formulated. Inclusion of the polymer slowed CS degradation and augmented the mechanical properties significantly. Chapters 3 and 4 explore the formation mechanism of tubular calcium phosphate structures from a gel/solution interface. Both the composition and microstructure of tubules were analogous to features of bone. To demonstrate the bone graft application of these structures, a model bone defect was augmented with particles that could generate tubular calcium phosphate in the presence of tissue. 3D computed tomography reconstructions revealed bone-like mineral deposition throughout the cavity. Chapter 5 explores the chemical coupling of hydroxyapatite particles within a PEEK matrix, a composite that may be used to fabricate spinal fusion devices. Physical properties of composites were improved by a reduction in HA debonding, the presence of fewer micro cracks, and more effective load transfer between phases. Together, the research puts forward a novel collection ofbiomaterials that may be applied to the treatment of bone fractures and fusion of the spine.

Type of Work:Eng.D. thesis.
Supervisor(s):Grover, Liam and Rowson, Neil and Cox, Sophie
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Additional Information:

Publications arising from thesis:

Hughes EAB, Yanni T, Jamshidi P, Grover LM. Inorganic cements for biomedical application: calcium phosphate, calcium sulphate and calcium silicate. Advances in Applied Ceramics. 2015;114(2):65-76.
http://dx.doi.org/10.1179/1743676114Y.0000000219

Hughes EAB, Grover LM. Characterisation of a novel poly (ether ether ketone)/calcium sulphate composite for bone augmentation. Biomater Res. 2017;21:7.
http://dx.doi.org/10.1186/s40824-017-0093-7

Hughes EAB, Williams RL, Cox SC, Grover LM. Biologically Analogous Calcium Phosphate Tubes from a Chemical Garden. Langmuir. 2017;33(8):2059-67.
http://dx.doi.org/10.1021/acs.langmuir.6b04574



Subjects:QH301 Biology
T Technology (General)
Institution:University of Birmingham
ID Code:8200
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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