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Design and fabrication of a next generation regenerative neural interface

Churm, James (2018)
Ph.D. thesis, University of Birmingham.

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Abstract

A Spiral Peripheral Neural Interface (SPNI) is an electrode array that has been previously presented as a regenerative neural interface capable of receiving information from, and transmitting information to nerves. The SPNI has previously been proven in concept, however, when stimulating nerves in the device, the electrodes areinsufficiently isolated from each other and stimulations can trigger unwanted neural activity in neighbouring channels of the SPNI. Along with this, neural interfaces generally, suffer from chronic viability problems, due to biological rejection. These issues were addressed in this thesis, by the addition of a PDMS silicone membrane, into the structure of the SPNI. Improvements to the understanding and performance of structural, electrical and biocompatibility aspects of the SPNI are addressed, with the addition of the PDMS film, which is used to electrically seal SPNI channels whilst not hindering conductor integrity. The inclusion ofPDMS also provides a platform which may enable drug delivery. This work dramatically improves SPNI performance whilst providing routes to improved biocompatibility. This thesis addresses the main issues previously presented in the SPNI and brings the device up to a new standard which can once again be tested for its viability in vivo.

Type of Work:Ph.D. thesis.
Supervisor(s):Tarte, Edward and Lancaster, Michael
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Electronic, Electrical and Systems Engineering
Additional Information:

Publications arising from thesis:

Hadis, M.A., Cooper, P.R., Milward, M.R., Gorecki, P., Tarte, E., Churm, J. and Palin, W.M., 2015, March. The effect of UV-Vis to near-infrared light on the biological response of human dental pulp cells. In SPIE BiOS (pp.930906-930906). International Society for Optics and Photonics.
http://dx.doi.org/10.1117/12.2077645


Hadis, M.A., Cooper, P.R., Milward, M.R., Gorecki, P., Tarte, E., Churm, J. and Palin, W.M., 2017. Development and application of LED arrays for use in phototherapy research. Journal of Biophotonics.
http://dx.doi.org/10.1002/jbio.201600273

Subjects:QH301 Biology
TK Electrical engineering. Electronics Nuclear engineering
Institution:University of Birmingham
ID Code:8198
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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