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The discrete multi-physics method applied to biomechanics

Ariane, Mostapha (2018)
Ph.D. thesis, University of Birmingham.

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Abstract

In this thesis, a fully Lagrangian approach called the Discrete Multi-Physics is adopted and applied to biomechanics. The Discrete Multi-Physics combines the Smoothed Particle Hydrodynamics, the Mass and Spring Model and the Discrete Element Method in a common particle-based framework. In the Discrete Multi-Physics, high deformations and contact of solid structures (e.g. valve’s leaflets during closing phase or colloid contact) can be easily modelled. In biological valve simulations, for instance, we were able to account for repeated opening-closing cycles and to introduce an agglomeration algorithm to model clotting. Besides cardiovascular and venous flows, we also applied the Discrete Multi-Physics to respiratory tracts for modelling (i) cilia motion and drug diffusion in the periciliary layer (ciliated epithelium) and (ii) the release of active ingredients in powder inhalers for drug delivery in the lungs.

Type of Work:Ph.D. thesis.
Supervisor(s):Alexiadis , Alessio and Barigou, Mostafa
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Additional Information:

Ariane, M., Allouche, M. H., Bussone, M., Giacosa, F., Bernard, F., Barigou, M. and Alexiadis, A. (2017). Discrete Multi-Physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation. Plos One, 12 (4).

http://doi.org/10.1371/journal.pone.0174795

Ariane, M., Wen, W., Vigolo, D., Brill, A., Nash, G. B., Barigou, M. and Alexiadis, A. (2017). Modelling and simulation of flow and agglomeration in deep veins valves
using Discrete Multi Physics. Computers in Biology and Medicine, 89: 96-103.

http://doi.org/10.1016/j.compbiomed.2017.07.020

Ariane, M., Vigolo, D., Brill, A., Nash, G. B., Barigou, M. and Alexiadis, A. (2017). Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves. Computers and Fluids. 166: 57-63.

http://doi.org/10.1016/j.compfluid.2018.01.037

Ariane, M., Stravos, K., Velaga, S. and Alexiadis, A. (2017). Discrete Multi-Physics simulations of diffusive and convective mass transfer in boundary layers containing motile cilia in lungs. Computers in Biology and Medicine, 95: 34-42.

http://doi.org/10.1016/j.compbiomed.2018.01.010

Ariane, M., M. Sommerfeld and A. Alexiadis (2018). Wall collision and drug-carrier detachment in dry powder inhaler: Using DEM to devise a sub-scale model for CFD calculations. Powder Technology 334: 65-75.

http://doi.org/10.1016/j.powtec.2018.04.051

Keywords:Discrete Multi-Physics, Smoothed Particle Hydrodynamics, Mass and Spring Model, Discrete Element Method, biological valve, clot-like solid, cilia, diffusivity, contact mechanics, dry powder inhaler
Subjects:QC Physics
TP Chemical technology
Institution:University of Birmingham
ID Code:8048
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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