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Exposure matters: effects of environmentally realistic exposure conditions on toxicity of model nanomaterials to Daphnia Magna

Nasser, Fatima (2018)
Ph.D. thesis, University of Birmingham.

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Nanomaterials (NMs) can be defined as having at least one external dimension between 1-100nm. Due to their small size, NMs have a large surface area giving them characteristics that differ from bulk material. NMs are incorporated into numerous applications making environmental exposure to NMs likely. Increased reliance on plastic results in accumulation of nano-plastics in fresh waters. Polystyrene (PS) acts as a representative of both nano-plastic and NMs. The deposition of gold (Au) NMs is also likely due to their use in medical applications so that both PS and Au have a potential to interact with environmental organisms. Daphnia manga (D. magna) is an ideal candidate in fresh water toxicity testing. Toxicity, uptake and retention of NMs by organisms is dependent on several factors such as NM charge, shape, chemical composition and the absorption of natural biomolecules binding to the surface of the NM creating an eco-corona, altering stability of the NMs thereby changing their toxicity. This work investigates the toxicity of PS and Au NMs and explores the effects of charge, shape, presence of a corona and the impact of realistic modes of presentation of NMs to D. magna and how these factors impact toxicity, uptake, retention and depuration.

Type of Work:Ph.D. thesis.
Supervisor(s):Lynch, Iseult and Valsami-Jones, Eugenia
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Geography, Earth and Environmental Sciences
Subjects:GC Oceanography
GE Environmental Sciences
Institution:University of Birmingham
ID Code:8002
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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