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Application and development of high-density functional near infrared spectroscopy for traumatic brain injury

Clancy, Michael (2017)
Ph.D. thesis, University of Birmingham.

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Functional near infrared spectroscopy (fNIRS) is a non-ionising, non-invasive, portable and relatively inexpensive method of measuring cerebral oxygen saturation. One potential application of fNIRS is as a monitoring modality for patients with traumatic brain injury (TBI) in order to guide therapy in both the emergency and clinical settings. However, despite its potential, uncertainty in signal origins (superficial contamination) has meant that current literature describes fNIRS as a 'work in progress' and as not currently suitable as a standalone technique to replace x-ray computerised tomography or invasive intracranial pressure monitors for TBI care. In order to address such limitations, the work within this thesis examined the viability of existing fNIRS devices, explored the utility of atlas-based reconstruction algorithms, and a prototype, high-density near infrared spectroscopy probe to improve the quantitative assessment of cerebral haemodynamics (including oxygen saturation) for use in TBI care. The presented data demonstrates that a high-density probe and Atlas-based reconstruction method is capable of more accurately mapping cerebral oxygen saturation than conventional fNIRS.

Type of Work:Ph.D. thesis.
Supervisor(s):Dehghani, Hamid and Lucas, Samuel
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:PSIBS Doctoral Training Centre
Subjects:QA75 Electronic computers. Computer science
QC Physics
RC Internal medicine
Institution:University of Birmingham
ID Code:7758
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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