The effect of exercise on oxidative stress and other health markers: exploring new technology and methodology

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Rai, Sahara (2017). The effect of exercise on oxidative stress and other health markers: exploring new technology and methodology. University of Birmingham. Ph.D.

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Abstract

Taking part in regular physical activity leads to adaptive response that enables the body’s antioxidant defence to be better equipped to fight against oxidative stress. Exercise intensity seems to be one of key factors that determines the effectiveness of exercise. The work presented in this thesis used novel approaches, through the application of emerging technologies, to study physical activity and its effects. This thesis contributes to the existing literature by being the first to investigate the effect of exercise on a marker of oxidative stress in the brain, an organ that becomes impaired (including oxidative damage) with ageing and diseases associated with ageing. The finding from this thesis suggests that brain glutathione (GSH) of young sedentary men as measured by magnetic resonance spectroscopy (MRS) was altered in response to acute exercise, in an exercise intensity dependent manner. Observed changes in peripheral markers of oxidative stress were also exercise intensity dependent. The brain seems to be protected against hyperperfusion injury during high intensity phase of high intensity interval exercise. Objectively measured physical activity levels were not significantly increased by an unsupervised home-based exercise intervention in older adults, potentially due to a lack of progressive goals based on adherence to physical activity.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Supervisor(s):
Supervisor(s)EmailORCID
Aldred, SarahUNSPECIFIEDUNSPECIFIED
Grant, MelissaUNSPECIFIEDUNSPECIFIED
Licence:
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Sport, Exercise and Rehabilitation Sciences
Funders: None/not applicable
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
URI: http://etheses.bham.ac.uk/id/eprint/7429

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