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Regime map development for co-rotating twin screw granulation

Tu, Wei-Da (2010)
M.Phil. thesis, University of Birmingham.

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Abstract

Continuous granulation is an important process for the future PAT (Processes analytical technology) initiative for the FDA. Therefore it is important to investigate the relationship between operating conditions and the granules. This thesis focused on one of the main equipments – twin screw extruder and attempted to develop the regime maps and the granulation hypothesis for twin screw granulation. In order to compare the mechanism with high-shear granulation that has been studied [1], the same materials were chosen (MCC (Microcrystalline cellulose) 102 and aqueous Polyethylene Glycol (PEG) 6000) and the regime maps were plotted by following similar operating conditions with reference [1]. One regime (granulation behaviour) was recognised for the short mixing geometry (16 mm, 30°), while three regimes (granulation, extrudates and blocked behaviours) were recognized for the long mixing geometry (64 mm, 30°). The regime maps suggested that the optimal granulation (narrow GSD (granule size distribution) and large mean granule size) can be achieved with a higher LS (Liquid-to-solid) ratio and a higher screw speed. The GSD was found further improved by reprocessing the same granules and/or manufacturing with aggressive mixing conditions.

Type of Work:M.Phil. thesis.
Supervisor(s):Seville, J. P. K. (Jonathan P. K.)
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Subjects:TP Chemical technology
Institution:University of Birmingham
ID Code:732
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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