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Economic analysis alongside multinational studies

Oppong, Raymond Awuah (2017)
Ph.D. thesis, University of Birmingham.

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Conducting economic evaluations alongside multinational studies presents a range of diverse challenges which have contributed to a lack of consensus on how they should be approached particularly because of the difficulties of resolving between country differences. This thesis examines the implications of conducting economic evaluation alongside multinational studies and (i) explores different approaches to obtaining unit costs; (ii) investigates the impact of using different tariffs to value EQ-5D health state descriptions; and (iii) provides a systematic comparison of the pooled and split approaches to economic evaluation alongside multinational trials. This study documents challenges that have been reported in published studies and makes recommendations to help researchers undertake economic evaluations alongside multinational studies.
Results indicate that the main challenge related to dealing with the differences between countries. Collecting unit cost data in all participating countries proved a difficult task, but was most effectively done by collaborating/direct contact with project partners and researchers/health economists from participating countries. Applying different EQ-5D value sets within the context of multinational trials did not make a difference to the conclusions in most cases. However, it is recommended that results from various tariffs are compared within sensitivity analysis. This study also showed that the choice of whether to pool or split the data can lead to different conclusions and recommendations about the cost-effectiveness of interventions. The culmination of this work is a 10 point checklist to guide good practice in the design, conduct and analysis of multinational economic evaluation studies and also highlights many areas where further research is needed. The work provides researchers, policy makers and stakeholders with additional insight into the economic analysis of multinational studies.

Type of Work:Ph.D. thesis.
Supervisor(s):Jowett, Susan and Roberts, Tracy
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Institute of Applied Health Research
Additional Information:

Publications resulting from research:

Oppong R, Coast J, Hood K, Nuttall J, Smith RD, Butler CC (2011) Resource use and costs of treating lower respiratory tract infections in 13 European countries: Challenges and Results European Journal of Health Economics 12 PP 319-329
DOI: 10.1007/s10198-010-0239-1

Oppong R, Kaambwa B, Nuttall J, Hood K, Smith RD, Coast J (2011) Assessment of the Construct Validity of EQ-5D in patients with acute cough/LRTI Applied Research in Quality of life 6(4) PP 411-423
DOI: 10.1007/s11482-011-9137-7

Oppong R, Kaambwa B, Nuttall J, Hood K, Smith RD, Coast J (2013) The Impact of Using Different Tariffs to Value EQ-5D health state descriptions: An example from a study of acute cough/LRTI in seven countries European Journal of Health Economics 14(2) PP 197-209
DOI: 10.1007/s10198-011-0360-9

Oppong R, Jit M, Smith RD, Butler CC, Melby H, Mölstad S, Coast J (2013) Cost-Effectiveness of Point of Care CRP Testing to Inform Antibiotic Prescribing Decisions British Journal of General Practice 63(612) PP e465- e471
DOI: 10.3399/bjgp13X669185

Oppong R, Jowett S, Roberts T (2015) Economic evaluation alongside multinational studies: A systematic review of empirical studies PLoS ONE 10(6)
DOI: 10.1371/journal.pone.0131949

Oppong R, Smith RD, Little P, Verheij T, Butler CC, Goossens H, Coenen S, Moore M, Coast J (2016) Cost-effectiveness of Amoxicillin for LRTI in Primary Care: An economic evaluation accounting for the costs of antimicrobial resistance British Journal of General Practice
DOI: 10.3399/bjgp16X686533

Subjects:HB Economic Theory
RA Public aspects of medicine
Institution:University of Birmingham
ID Code:7288
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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