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The scale up of air-filled emulsion production

Critchley, Liam John (2016)
M.Sc. thesis, University of Birmingham.

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An Air-Filled Emulsion (AFE) is a dispersion of particles, of colloidal size, which are generally characterised from sub-micron to ten microns in diameter. They are produced by unfolding proteins so that the disulphide bonds in the protein react with superoxide radicals to form ‘air cells’. These air cells are what form the non-aqueous phase in AFEs. The aim of this project was to see if the production of AFEs could be scaled up from bench to pilot scale. Results showed that recycle methods produced up to 98.7 % AFE yield with two out of three top-up methods (STUM) producing >90 % AFE yield. Other methods which were non-top-up (NoTUM) did not produce a high yield, but showed that air cells are robust enough to withstand multiple passes of sonication waves and heating. These methods yielded the first continuous method of AFE production. This was adapted to produce a novel way of isolating and concentrating formulation-ready AFE, which was concentrated up to 6-times previously found using a cross-flow filtration module. Work on the pilot scale produced the first AFE sample beyond the bench scale, and combined with the novel methods it provides a promising benchmark to take the production to larger scales in the future.

Type of Work:M.Sc. thesis.
Supervisor(s):Simmons, Mark J. H. and Cox, Philip William
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Biosciences
Subjects:QD Chemistry
TP Chemical technology
Institution:University of Birmingham
ID Code:7107
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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