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Developing nucleophilic nitrenoids for the synthesis of complex heterocycles

Garzon Sanz, Miguel (2016)
Ph.D. thesis, University of Birmingham.

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Abstract

The combination of nucleophilic nitrenoids and gold-catalysis has rapidly emerged as a powerful tool in the assembling of different nitrogen-containing motifs. The research presented in this thesis describes the advances in the field and the exploration of pyrimidium \(N\)-heteroaryl aminides as building blocks in the formation of several fused imidazoheterocycles.
From the initial discovery of this reaction and its application in the synthesis of imidazo[1,2-a]pyrimidines, the scope of this convergent gold-catalysed strategy has been adapted to allow the access to fourteen classes of biologically relevant structures. The proposed mechanism and optimisation will be discussed alongside the accommodation of a wide range of useful functionalities difficult to introduce by other methodologies.

Type of Work:Ph.D. thesis.
Supervisor(s):Davies, Paul
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Additional Information:

Embargo till 31/12/2017

Subjects:QD Chemistry
Institution:University of Birmingham
ID Code:7060
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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