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The peripheral nervous system: injury and disease

Gordon, Tessa (2016)
D.Sc. thesis, University of Birmingham.

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Abstract

Poor functional outcomes are frequent after peripheral nerve injuries despite the regenerative support of Schwann cells. Whilst motoneurons and to a lesser extent, sensory neurons survive the injuries, outgrowth of axons across the injury site is slow and the neuronal regenerative capacity is progressively reduced when neurons remain without targets and chronically denervated Schwann cells fail to support axon growth. Strategies including brief low frequency electrical stimulation that accelerates axon outgrowth and, in turn, target reinnervation and functional recovery, have excellent potential for translation to human patients. Other strategies including the insertion of cross-bridges between a donor nerve and a recipient denervated nerve stump, are effective in promoting functional outcomes after complete injuries. During muscle reinnervation the properties of the motoneurons and muscle fibers that they supply are rematched that provide some control of muscle force even when regenerating axons are misdirected to foreign targets. Axon sprouting from intact nerves is effective, although limited, in reinnervating denervated muscle fibers after incomplete injuries and in poliomyelitis. Studies in mouse models of amyotrophic lateral sclerosis however, indicate that sprouting is very limited with rapid and preferential loss of the largest and fastest contracting motor units during the asymptomatic phase of the disease.

Type of Work:D.Sc. thesis.
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Institute of Clinical Sciences
Additional Information:

Higher Doctorate by Prior Publication. Please see Publication List for thesis contents.

Subjects:QP Physiology
RC Internal medicine
Institution:University of Birmingham
ID Code:6822
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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