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Spinal implants - the problems of debris

Eckold, David Geoffrey (2016)
Ph.D. thesis, University of Birmingham.

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Wear debris are known to incite a variety of biological responses when released from a joint replacement device. One such response is known as osteolysis-pathological destruction of bone. Osteolysis is the major cause of failure in joint replacements. The loss of bone around a joint replacement may cause an aseptic loosening of the implant and reduce options for revision surgery. The intervertebral disc may be replaced with a joint replacement device. Often, this is done with a ball on socket joint using a metal-on-polymer material combination. Ultra-high molecular weight polyethylene (UHMWPE), inherited from hip and knee implants, is a common choice in lumbar disc replacements.
The wear debris from a Charité implant, tested in vitro, was characterised using computer vision techniques and machine learning. It was found that wear debris from this UHMWPE and metal implant produce debris that are particularly prone to illicit an immune reaction that could lead to osteolysis.
To counter the release of wear debris into periprosthetic tissue where it can do harm, laser sintered Polyetherketoneketone (PEKK) was wear tested in an attempt to capture wear debris in the surface voids formed by the manufacturing process. Despite literature suggesting this could work, wear tests showed sintered PEKK is unsuitable as a bearing material.

Type of Work:Ph.D. thesis.
Supervisor(s):Dearn, Karl and Shepherd, Duncan E. T.
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Engineering
Subjects:TJ Mechanical engineering and machinery
Institution:University of Birmingham
ID Code:6796
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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