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Investigation into the production of a particle-in-particle system for the treatment of hepatocellular carcinoma by transarterial chemoembolization

McCarry, Patrick Michael (2016)
Ph.D. thesis, University of Birmingham.

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Transarterial Chemoembolization (TACE) is a leading therapy in patients suffering from intermediate hepatocellular carcinoma (HCC). TACE is a transarterial therapy that involves injection of particles and chemotherapeutic agents to the tumour site. Once administrated, the particles block the blood flow to the tumour while also allowing targeted delivery. Several therapies have proven to increase survival in people suffering from HCC where drug eluting beads (DEBs) have become a frequently used method. Despite their success, DEBs are limited to drugs that interact with the embolizing material’s functional groups. Also, the embolizing beads must be calibrated to a patient’s blood vessel size where smaller sized beads will display faster release rates. In order to overcome these disadvantages, a Particle-in-Particle (PIP) system is proposed. Small microparticles (1 – 3 µm) are to be manufactured to suit a specific drug where they will function as a drug delivery component. These microparticles are then to be encapsulated into larger microparticles (100 – 1000 µm) which will act as an embolizing component of the PIP system. Polymers and particle production methods are to be investigated in order to produce a PIP system capable of targeted delivery of a wider class of drugs with identical release rates.

Type of Work:Ph.D. thesis.
Supervisor(s):Bridson, Rachel H and Greenwood, Richard
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:Department of Chemical Engineering
Subjects:RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RM Therapeutics. Pharmacology
TP Chemical technology
Institution:University of Birmingham
ID Code:6766
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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