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Imaging the development of a bone-to-bone ligament construct

Bannerman, Alistair L. (2016)
Ph.D. thesis, University of Birmingham.

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Abstract

Ligament injuries are commonplace, with poor native healing leaving injury sites exposed to instability and further damage. A number of surgical methods have been established for reconstruction using a range of materials, but these have a high failure rate and a number of undesirable side-effects. Much recent work has been focused on the development of tissue engineered ligament grafts. One of the major challenges for this is the formation of an effective ligament-bone interface. In native tissue a multi-phase interface enables smooth transfer of forces between the mechanically mismatched bone and ligament tissue, however this has proved hard to replicate. Previous work has developed a bone-bone ligament construct model intended to emulate the native interface through formation of a mineralised region by soluble cement anchors. Development and optimisation of the model has seen an increasing mechanical strength, but the mechanisms involved are poorly understood. This study investigates the development of the ligament construct through the use of multiple complimentary imaging techniques to provide information on the biological, chemical, and topological development of the construct as it forms from initially homogeneous and separate materials to a complex non-homogeneous system.

Type of Work:Ph.D. thesis.
Supervisor(s):Grover, Liam and Mendes, Paula and Dehghani, Hamid
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Additional Information:

Publications connected with doctoral research:

Bannerman, Alistair, Jennifer Z. Paxton, and Liam M. Grover. "Imaging the hard/soft tissue interface." Biotechnology letters 36.3 (2014): 403-415. http://dx.doi.org/10.1007/s10529-013-1374-4

Koburger, Susanne, et al. "A novel method for monitoring mineralisation in hydrogels at the engineered hard–soft tissue interface." Biomaterials Science 2.1 (2014): 41-51. http://dx.doi.org/10.1039/C3BM60102A

Subjects:QP Physiology
TP Chemical technology
Institution:University of Birmingham
ID Code:6425
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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