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Articulated statistical shape models for the analysis of bone destruction in mouse models of rheumatoid arthritis

Brown, James (2015)
Ph.D. thesis, University of Birmingham.

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Abstract

Rheumatoid arthritis is an autoimmune disease that affects approximately 1% of the population, where chronic inflammation of the synovial joints can lead to active destruction of cartilage and bone. New therapeutic targets are discovered by investigating genes or processes that exacerbate or ameliorate disease progression. Mouse models of inflammatory arthritis are commonly employed for this purpose, in conjunction with biomedical imaging techniques and suitable measures of disease severity. This thesis investigated the hypothesis that a statistical model of non-pathological bone shape variation could be used to quantify bone destruction present in micro-CT images. A framework for constructing statistical shape models of the hind paw was developed, based on articulated registration of a manually segmented reference image. Successful registration of the reference towards ten healthy hind paw samples was followed by statistical shape analysis. Mouse models of inflammatory arthritis were then investigated and compared by identifying bone abnormalities as deviations from the model statistics. Validation of the model against digital phantoms and clinical scores indicates that the method is largely successful in this effort. Application of the method in a novel study of macrophage-mediated inflammation shows promising results that are supportive of previous findings.

Type of Work:Ph.D. thesis.
Supervisor(s):Naylor, Amy and Claridge, Ela and Styles, Iain B and Filer, Andrew (Dr)
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Additional Information:

Publication resulting from research: Brown, James M., et al. "3D Articulated Registration of the Mouse Hind Limb for Bone Morphometric Analysis in Rheumatoid Arthritis." Biomedical Image Registration. Springer International Publishing, 2014. 41-50. http://dx.doi.org/10.1007/978-3-319-08554-8_5

Subjects:QA75 Electronic computers. Computer science
QA76 Computer software
QH301 Biology
QR180 Immunology
RC Internal medicine
Institution:University of Birmingham
ID Code:6349
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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