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Manufacturing of a fast-dissolving dosage form - investigating powder handling and control of surface characteristics

Aslam, Omar Shezad (2010)
M.Res. thesis, University of Birmingham.

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Abstract

An early stage in the manufacture of a proprietary fast dissolving dosage form (FDDF), involves dissolution/suspension of the active agent in an aqueous solution. To allow use of aqueous labile drugs and/or coated drug particles in the FDDF, the development of an alternative approach is sought i.e. that which allows independent dosing of drug powders and liquid components. The focus of this work is on the powder dosing aspect. A vacuum based filling system was investigated and was generally shown to be capable of delivering accurate 50 mg and 400 mg doses of model drug particles with high precision (RSD <2 %). The investigated model materials included coated sugar spheres, paracetamol, ibuprofen and excipient powders with typical diameters between 100 μm-500 μm. The strength of vacuum used to collect the powder was seen to affect the dose weight for certain materials more than others; the magnitude of this effect was linked to the Carr’s Index. The dosing equipment was shown to be capable of collecting doses rapidly (< ½ second), hence being suitable for a potential, future automated process.

Type of Work:M.Res. thesis.
Supervisor(s):Bridson, Rachel and Bakalis, Serafim and Wong, Desmond
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Subjects:TP Chemical technology
Institution:University of Birmingham
ID Code:627
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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