An investigation of granulated sugar dressing in the management of sloughy, necrotic and infected exuding wounds

Murandu, Moses Donald (2015). An investigation of granulated sugar dressing in the management of sloughy, necrotic and infected exuding wounds. University of Birmingham. Ph.D.

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Abstract

Aim: Investigated the use of granulated sugar in the management of sloughy, necrotic and infected exuding wounds.
Method: The investigation followed the Medical Research Council (MRC, 2007) framework for investigation of complex interventions.
Pre-clinical: The study was registered with MHRA, followed by development and design of the mode of sugar delivery to patient use.
Evidence review: A systematic review and meta-analysis concluded that there was no existing good quality evidence to support the routine use of sugar dressings.
Phase I: Laboratory studies found that all three sugars showed relatively equal activity against all the bacteria tested although Demerara sugar was slightly less active.
Phase II: A feasibility study of 22 patients concluded that both insulin and non-insulin treated diabetic patients can be treated with sugar dressing without affecting their blood sugar levels.
Phase III: A randomised controlled trial failed to recruit the intended numbers and final analysis was carried out on 22 patients randomised to sugar and 19 randomised to usual care. 19 (86%) achieved debridement at 4 weeks in the sugar group compared to 6 (32%) standard care group (Fisher’s exact test: p<0.001).
Overall conclusion: Sugar has an effect on micro-organisms and can be used in modern hospitals and community settings.

Type of Work:

Thesis (Doctorates > Ph.D.)

Award Type:

Doctorates > Ph.D.

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