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Design and fabrication of novel regenerative implant based on polymeric material

Benmerah, Samia (2015)
Ph.D. thesis, University of Birmingham.

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This thesis presents the design and the fabrication process of a three-dimensional (3D) neural interface consisting of a bundle of parallel micro-channels with (100μmx100μm) cross-sectional area and embedded micro-electrodes. This is a regenerative implant that is able to stimulate and record extracellular neural signals in the peripheral nervous system as demonstrated by the \(in-vivo\) experiments conducted in collaboration as part of this project. These implants have the potential to be developed into long-term neural interfaces capable of extracting neural signals from stumps of severed peripheral nerves to use as control inputs for muscles simulators or artificial limbs for amputees. The skeleton of the device is entirely made of flexible polyimide films. Gold micro-electrodes and micro-channels of photosensitive polyimide are patterned directly on polyimide substrates. After fabrication, the 2D electrode micro-channel array is rolled into a 3D structure forming concentric rolls of closed micro-channel arrays with a Swiss-roll like arrangement. Microflex Interconnection technique (MFI) was incorporated successfully into the implant. The performance of the implant microelectrodes was characterised \(in-vitro\) through impedance spectroscopy and \(in-vivo\) via implantation in animals for three months. The ability of the electrodes to stimulate and capture action potentials from regenerated tissue was also assessed.

Type of Work:Ph.D. thesis.
Supervisor(s):Tarte, Edward
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:Department of Electronic, Electrical and Systems Engineering
Subjects:RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
TK Electrical engineering. Electronics Nuclear engineering
Institution:University of Birmingham
ID Code:5661
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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