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Influence of plasma proteins on setting characteristics of mineral trioxide aggregate like cement

AbuOnq, Zaid (2010)
M.Phil. thesis, University of Birmingham.

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Abstract

Mineral trioxide aggregate (MTA) is a modified Portland cement (PC) based dental material containing bismuth oxide (Bi2O3) as a radiopacifier that is presently used as a sealing material in endodontic treatment. The present study investigated the influence of albumin, fibrinogen and γ-globulin, the three most abundant blood plasma proteins, both individually and in combination on the setting time, compressive strength and relative porosity of an MTA-like dental cement. The cement powder formulation was mixed with the liquid phase containing normal plasma protein concentrations or quarter, double or quadruple the normal plasma protein concentration as well as a mixture of all three proteins. Compressive strength and relative porosity were measured from 2 to 56 days and the initial setting times were determined using the Gilmore needles test. The set cement microstructure was examined using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The compressive strength of all cements increased with time whereas strut density and relative porosity decreased. Fibrinogen and γ-globulin increased setting time with increasing concentration while albumin acted as an accelerant. For the MTA model mixed with all three plasma proteins, the setting times decreased as concentrations were increased.

Type of Work:M.Phil. thesis.
Supervisor(s):Shelton, Richard M.
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Dentistry
Subjects:RK Dentistry
Institution:University of Birmingham
ID Code:557
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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