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Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol

Takebayashi, Yuiko (2015)
Ph.D. thesis, University of Birmingham.

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Abstract

Thiomarinol is a novel hybrid antibiotic produced by \(Pseudoalteromonas\) \(rava\) sp. nov. SANK 73390. It is structurally similar to a clinically significant antibiotic mupirocin, but includes an additional pyrrothine moiety joined to the mupirocin-like marinolic acid via an amide bond. Thiomarinol has been shown to be more potent against a wider range of microorganisms. This potency was hypothesised to be due to either an increase in inhibition of its target enzyme, isoleucyl-tRNA synthetase (IleS) or an increase in antibiotic uptake and/or inefficient efflux by bacterial cells or a combination of both. This thesis describes experiments that investigate the basis for this increase in potency.

Type of Work:Ph.D. thesis.
Supervisor(s):Thomas, Christopher M. and Winn, Peter J
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Biosciences
Subjects:QR Microbiology
QR180 Immunology
Institution:University of Birmingham
ID Code:5562
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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