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The impact of high fat diet and chronic intermittent hypoxia on glucose control and cardiorespiratory function

Smith, Christopher William (2014)
M.Res. thesis, University of Birmingham.

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Abstract

Previous studies have demonstrated carotid body (CB) activity is increased in a high fat diet (HF) induced model of insulin resistance (IR), and carotid sinus nerve resection prevents this and the associated hypertension (HT). The chronic intermittent hypoxia (CIH) of obstructive sleep apnoea also results in HT. We therefore hypothesised the combination of HF induced IR and CIH would result in further increase of CB activity and HT. Effects of HF and CIH on cardiorespiratory parameters, IR, CB activity and sympathetic output were assessed in anaesthetised Wistar rats. HF rats developed obesity, IR and ventricular hypertrophy, with CIH reducing weight gain, but not affecting IR or hypertrophy. Mean arterial blood pressure (MABP) in HF rats tended to be increased by 12±3mmHg, with systolic BP significantly increased. In combination with CIH, MABP tended to be increased by 10±3mmHg, with systolic BP not significantly increased. Treatment groups showed no increased ventilatory drive or sympathetic activity. In conclusion, HF induces obesity, IR and ventricular hypertrophy, however did not result in significant MABP increase. In combination with CIH, obesity is reduced however IR, hypertrophy and MABP do not appear to be affected. Also neither HF diet nor CIH cause increased CB or sympathetic activity.

Type of Work:M.Res. thesis.
Supervisor(s):Coney, Andrew and Ray, Clare
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Clinical and Experimental Medicine
Subjects:RC Internal medicine
Institution:University of Birmingham
ID Code:5548
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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