Investigating the sources and magnitude of human exposure to halogenated organic pollutants using advanced methods for environmental analysis.

Abdallah, Mohamed Abdel Galil Abou-Elwafa (2010). Investigating the sources and magnitude of human exposure to halogenated organic pollutants using advanced methods for environmental analysis. University of Birmingham. Ph.D.

[img]
Preview
abullah10PhD.pdf
PDF

Download (4MB)

Abstract

Analytical methods based on LC-ESI-MS/MS or LC-APPI-MS/MS were developed and/or validated for the separation and determination of BDE-209 and TBBP-A, in addition to HBCD diastereomers, enantiomers and degradation products in a wide range of samples including air, dust, diet, simulated GIT fluid, human serum and breast milk. The obtained concentrations were used to estimate the exposure of adults, toddlers and nursing infants to the target BFRs via inhalation, dust ingestion and diet using different exposure scenarios and the relative importance of each exposure pathway was assessed for the studied age groups. Causes of variability in concentrations of HBCDs in indoor dust were elucidated and forensic microscopy techniques were used to study the mechanisms of transfer of BDE-209 and HBCDs to indoor dust. A colon-enhanced physiologically based extraction model was developed and applied for the first time to study the bioaccessibility of target BFRs from human GIT. Exposure via dust ingestion, but not diet, correlated significantly (p<0.01) with ΣHBCDs in serum of 16 adults. The levels of target BFRs were reported for the first time in 28 human milk samples from the UK. The relationship between adult intake of BFRs and the observed body burdens was studied using a pharmacokinetic model. Although no enantioselective enrichment was detected in either dust or diet, enrichment of (-)-α-HBCD was observed in both human serum and milk which may be attributable to enantioselective absorption, metabolism and/or excretion.

Type of Work: Thesis (Doctorates > Ph.D.)
Award Type: Doctorates > Ph.D.
Supervisor(s):
Supervisor(s)EmailORCID
Harrad, StuartUNSPECIFIEDUNSPECIFIED
Harrison, RoyUNSPECIFIEDUNSPECIFIED
Licence:
College/Faculty: Colleges (2008 onwards) > College of Life & Environmental Sciences
School or Department: School of Geography, Earth and Environmental Sciences
Funders: None/not applicable
Subjects: Q Science > Q Science (General)
URI: http://etheses.bham.ac.uk/id/eprint/546

Actions

Request a Correction Request a Correction
View Item View Item

Downloads

Downloads per month over past year