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Multi-modal diffuse optical tomography and bioluminescence tomography system for preclinical imaging

Guggenheim, James A. (2014)
Ph.D. thesis, University of Birmingham.

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The development, characterisation and testing of a novel all-optical, multi-modal preclinical biomedical imaging system is presented. The system aims to provide a new way of accurately visualising the spatial distribution and activity of molecular structures and processes in small animals by combining 3D bioluminescence tomography (BLT; reconstruction-based 3D imaging of internal bioluminescent reporter distributions), diffuse optical tomography (DOT; reconstruction-based imaging of optical parameter distributions) and optical surface capture techniques. The key principle of the imaging system is to use surface capture results to enhance the accuracy of DOT image reconstruction, and to use the results of both surface capture and DOT to enhance the accuracy of BLT. Presented experiments show that the developed system can reconstruct luminescent source distributions and optical parameters accurately and that small animal imaging is feasible with the system.

Type of Work:Ph.D. thesis.
Supervisor(s):Dehghani, Hamid and Styles, Iain B
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:PSIBS Doctoral Training Centre
Subjects:T Technology (General)
Institution:University of Birmingham
ID Code:5278
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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