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Studies on the lubrication of roller compaction formulations

Dawes, Jason (2014)
Eng.D. thesis, University of Birmingham.

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Abstract

The tablet is the preferred route of delivery for pharmaceutical products to its relative ease of manufacture and high patient compliance. However, complex tablet formulations can present a number of process challenges, necessitating careful design of both the formulation and the process. This thesis sets out to investigate some of the issues involved with the lubrication of roller compaction formulations in order to gain a greater understanding of the role of lubrications.
A systematic study on the effect of magnesium stearate during feeding and compaction in a horizontally fed roller compactor has been conducted. The feasibility of a novel external lubrication was investigated as an engineering solution to prevent adhesion to roll surfaces in the absence of magnesium stearate from the formulation. Alternative formulation strategies and lubricants have been investigated to find suitable materials that provide similar lubricating properties to magnesium stearate whilst exhibiting less detrimental effects on the tablet strength and tablet dissolution. The feasibility of using surrogate APIs as an aid to facilitate process and formulation design of investigational drug products was tested using a statistical analysis of the response data obtained from an experimental design.

Type of Work:Eng.D. thesis.
Supervisor(s):Greenwood, Richard and Gamble, John and Robbins, Phil and Tobyn, Michael
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Additional Information:

Embargo expiry: 31/07/2018

Subjects:TP Chemical technology
Institution:University of Birmingham
ID Code:5160
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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