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Project 1 Molecular genetic analysis of m6A methylation of mRNA in a Drosophila Model Project 2 Development of a phenotypic highthroughput-screening assay to identify novel molecules that inhibit Mycobacteria

Kanvatirth, Panchali (2014)
M.Res. thesis, University of Birmingham.

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Abstract

Project 1:
The genetic information on living systems is relayed from the DNA to protein through a chain of important processes. Various pathways regulate the process of mRNA synthesis into proteins among which methylation is an important one. Internal methylation has known regulate alternate splicing and regulate neuronal development. Knocking out genes involved in synthesis of proteins binding to methylated sites on the mRNA leads to an understanding of how the proteins with the modified mRNA modulate the neuronal development. This project utilizes Drosophila as a model organism to study the effects of the knock outs.
Project 2:
Tuberculosis and important disease, which has plagued mankind since centuries. With the development of modern drug regimens it was assumed that the disease is cured but with recent rise in drug resistant strains the current drug therapies are failing to control the spread of the disease. Combined with a high level of immunocompromised patients the bacilli has been able to invade further and increase the number of mortality rates. The current scenario of drug discovery involves highthroughput screening of new compounds and drugs, which are being synthesized, by chemists and pharamceuticals. The HTS methodology for screening requires a robust and reliable assay to give indications about new inhibitory compounds against Mycobacteria.

Type of Work:M.Res. thesis.
Supervisor(s):Soller, Matthias and Alderwick, Luke
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Bioscience
Subjects:QR Microbiology
RB Pathology
Institution:University of Birmingham
ID Code:5141
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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