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Novel processing routes for neural interfaces

Barrett, Richard (2014)
Ph.D. thesis, University of Birmingham.

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Abstract

The thesis describes novel processing routes that have been developed to fabricate neural interfaces.
A process has been investigated that uses microfabrication techniques to fabricate a multi-channel regenerative implant that can record nerve impulses in the peripheral nervous system (PNS), called the Spiral Peripheral Nerve Interface (SPNI). It is shown both theoretically and experimentally that the implant improves the ability to record signals in the PNS via micro-channels that act as axonal amplifiers. New processing routes are introduced to create robust interconnections from the SPNI to external electronics via ‘Microflex’ technology. To incorporate the new interconnection technology the SPNI had to be modified. During this modification the strain in the device was given specific consideration, for which a new bending model is presented. Modelling is used to show that electrochemical impedance spectroscopy can be used to assess the quality of the fabrication process. Electrochemical and mechanical tests show that the interconnection technology is suitable for a neural interfaces but the fabrication of perfectly sealed micro-channels was not evident. Thus, the SPNI was further improved by the introduction of a silicone sealing layer in the construction of the micro-channel array that was implemented using a novel adhesive bonding technique.

Type of Work:Ph.D. thesis.
Supervisor(s):Tarte, Edward
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Electrical, Electronics and Computer Engineering
Subjects:TK Electrical engineering. Electronics Nuclear engineering
Institution:University of Birmingham
ID Code:5137
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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