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# The role of oxygen-dependent substances in exercise

Davies, Christopher S. (2013)
Ph.D. thesis, University of Birmingham.

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## Abstract

This thesis investigated the role of O$$_2$$-dependent substances in mediating the vasodilatation seen following exercise (post-exercise hyperaemia) and in fatigue development. Additionally we compared young and old subjects to investigate the effects of ageing in both of these phenomena.
Breathing supplementary 40% O$$_2$$ during handgrip exercise at 50% of maximum voluntary contraction had no effect of the magnitude of post-exercise hyperaemia compared to air breathing control. Furthermore, aspirin administration did not alter magnitude of post-exercise hyperaemia or the levels of prostaglandin E metabolites assayed from the forearm venous efflux. Similarly the magnitude of post-exercise hyperaemia was not affected by aminophylline administration. Collectively these suggest that prostaglandins and adenosine are not obligatory mediators of post-exercise hyperaemia.
Supplementary O$$_2$$ breathed during recovery had no effect on fatigue in a second bout of exercise or any of the substances proposed to mediate fatigue, in young subjects. We demonstrated that older subjects showed no changes in the magnitude of post-exercise hyperaemia, but they were more fatigue resistant. There was no O$$_2$$-dependence of either post-exercise hyperaemia or fatigue in older subjects.
In conclusion, we have found no evidence of O$$_2$$-dependent mediators in either post-exercise hyperaemia or fatigue.

Type of Work: Ph.D. thesis. Marshall, Janice Colleges (2008 onwards) > College of Medical & Dental Sciences School of Clinical and Experimental Medicine R Medicine (General)RC1200 Sports Medicine University of Birmingham 4273
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