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The physics, dosimetry and microdosimetry of boron neutron capture theraphy

Ghani, Zamir (2013)
Ph.D. thesis, University of Birmingham.

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A validated experimental and numerical procedure is described detailing macroscopic and microscopic dose calculations forming the basis of a protocol for the pre-clinical biological characterisation of the University of Birmingham’s BNCT facility.

Fundamental reference dosimetric measurements have been carried out at the University of Birmingham’s accelerator based NCT facility and the Massachusetts Institute of Technology (MIT) research reactor to characterise macroscopic and microscopic doses and derive correction factors for the irradiation of V79 cells incubated in boric acid and irradiated as monolayers. On and off-axis thermal neutron, fast neutron and photon doses have been measured and calculated with standard macroscopic dosimetry techniques (foils and ion chambers) from which normalised MCNPX calculations are used to derive perturbation factors and off-axis corrections for cell flask irradiations.

Microdosimetric correction factors are calculated for the boron dose component using Monte Carlo methods to simulate lithium ion and alpha particle tracks in semi-stochastic geometries representative of cell monolayer irradiations, incubated in a medium with 50ppm boric acid. Further simulations of recoil protons from nitrogen capture reactions allow for the calculation of correction factors for the non-uniform distribution of the nitrogen dose at the cellular level.

Type of Work:Ph.D. thesis.
Supervisor(s):Green, Stuart
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Physics and Astronomy
Subjects:QC Physics
Institution:University of Birmingham
ID Code:4000
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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