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Investigation of techniques for the surface roughness characterisation of bovine articular cartilage

Ghosh, Siddharth (2012)
M.Phil. thesis, University of Birmingham.

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Abstract

This thesis investigates the surface roughness of healthy bovine humeral lateral condyle articular cartilage using a nontrivial technique of three-dimensional electron-topography with stereoscopic approach. It is a non-contact roughness characterisation with high resolution using elementary particle electron. Eucentric scanning electron microscopic (SEM) images of different magnifications (500×, 800×, 1200× and 2000×) were used for topographic reconstruction. After reconstruction, roughness has been extracted from the 3D topography. The technique was verified with a commercial standard surface of nanoscale roughness to determine its reliability by repeating with six samples. The roughness values obtained in different magnifications for six samples were compared and calibrated with atomic force microscopy (AFM). Then the method of 3D-ET was employed on four articular cartilage surfaces. The results for both the surfaces showed that surface roughness increased with magnification and thumb-rule relation has been derived. The obtained roughness values for articular cartilage range from 165 nm to 418 nm for magnification of 500× to 2000×. The cartilage samples were also calibrated with AFM and a constitutive relation between them has been derived. The thesis aims to provide a breakthrough of non-contact surface roughness analysis for mimicking articular cartilage to artificial materials for replacement therapy.

Type of Work:M.Phil. thesis.
Supervisor(s):Shepherd, Duncan E. T.
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:Bio-medical and Microengineering Research Centre, School of Mechanical Engineering
Subjects:QH301 Biology
RD Surgery
TJ Mechanical engineering and machinery
Institution:University of Birmingham
ID Code:3642
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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