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Using repeated measures of blood biomarkers and physical biomeasures to define changes in volume status in patients with decompensated heart failure, normal volunteers and patients with stable left ventricular systolic dysfunction

Ng Kam Chuen, Marie Jennyfer (2012)
M.D. thesis, University of Birmingham.

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Abstract

Background
The non-invasive assessment of volume status in left ventricular systolic dysfunction (LVSD) is challenging. The main thesis objective was to establish the feasibility and potential clinical utility of repeated measures assessment of non-invasive biomarkers in defining changes in volume status within individual volunteers.
Methods
Differential volume manipulation protocols were achieved in a three-staged plan of investigation[…]
Results Summary
I demonstrated the smallest variance for bioimpedance measures, and the largest variance for urine biomarkers […]
Conclusion
The repeated measures of biomarkers studied in response to different volume manipulations were interpreted in the context of their within-subject normal variance. None of the biomarkers studied appeared to have the ideal characteristics clinically for the monitoring of subclinical changes in volume status in stable LVSD or in response to acute diuresis in decompensated heart failure. The significant increases in urine biomarkers following diuretic withdrawal in stable LVSD suggested potentially beneficial renal effects of furosemide in
stable LVSD.

Type of Work:M.D. thesis.
Supervisor(s):MacFadyen, Robert J. and Lip, Gregory Y. H.
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Centre for Cardiovascular Sciences
Subjects:QH301 Biology
QP Physiology
RC Internal medicine
Institution:University of Birmingham
ID Code:3617
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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