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Are angiogenic stimuli additive? A study in the rat correlating structure and function

George, Daniel (2012)
M.Res. thesis, University of Birmingham.

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Abstract

The aim of this study was to elucidate whether two different types of angiogenic stimuli, known to elicit two fundamentally different types of angiogenesis in rat hindlimb skeletal muscle, produce an additive effect when applied simultaneously. When administered in drinking water, the α-1 adrenoreceptor antagonist, prazosin, elevates shear stress causing splitting angiogenesis in extensor digitorum longus (EDL) muscle; surgical extirpation of the tibialis anterior (TA) muscle, a synergist, induces sprouting angiogenesis in EDL muscle due to overload. We used an in vivo rat preparation to investigate how functional readouts of EDL muscle performance and hindlimb blood flow, upon indirect electrical stimulation of the common peroneal nerve, were changed, if at all, once these different types of angiogenesis had been induced. Muscle samples were analysed for structural changes and correlated with function changes, for each treatment group.

Type of Work:M.Res. thesis.
Supervisor(s):Egginton, Stuart and Ray, Clare
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Clinical and Experimental Medicine
Subjects:QH301 Biology
QP Physiology
R Medicine (General)
Institution:University of Birmingham
ID Code:3534
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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