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Short echo time single voxel magnetic resonance spectoscopy in the characterisation of childhood brain tumours.

Harris, Lisa Maria (2009)
Ph.D. thesis, University of Birmingham.

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Abstract

INTRODUCTION
Brain tumours are the most common solid tumour in childhood, while Magnetic Resonance Spectroscopy (MRS) studies have been performed on brain tumours previously, the majority have been performed on the adult patient population and at long echo times. The work presented in this thesis outlines work performed in the usage of short echo time MRS in the characterisation of childhood brain tumours.

METHODS
Short echo time MRS was performed on children with brain tumours at the time of diagnostic imaging. In addition, follow up data was accrued for some patients. Resulting spectra were assessed for characteristics either of diagnosis, prognosis or treatment response.

RESULTS
Spectra collected were used in assessing characteristics of an array of childhood brain tumours. Initially the technique was tested on a well understood dataset of cerebellar tumours, and was later expanded to provide diagnostic aids for both brain stem tumours and pineal region tumours. A group of pilocytic astrocytomas were assessed for differences by location within the brain, for prognosis and for response to treatment.

CONCLUSIONS
The additional information given by short echo time MRS was useful in the characterisation of childhood brain tumours

Type of Work:Ph.D. thesis.
Supervisor(s):Peet, Andrew (Dr) and Arvanitis, Theodoros N.
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Institute of Child Health
Subjects:RJ Pediatrics
RJ101 Child Health. Child health services
Institution:University of Birmingham
ID Code:348
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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