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Experimental and computational dosimetry of laser-driven radiation beams

Fiorini, Francesca (2012)
Ph.D. thesis, University of Birmingham.

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Abstract

Laser-driven particle acceleration is an area of increasing research interest given the recent development of short pulse high intensity lasers. A significant difficulty in
this field is given by the exceptionally large instantaneous dose rates which such particle beams can produce. This represents a challenge for standard dosimetry
techniques and more sophisticated procedures need to be explored. In this thesis I present novel detection and characterisation methods using a combination of GafChromic films, TLD chips, nuclear activation and Monte Carlo simulations, applicable to laser-driven beams. Part of the work is focused on the detection of laserdriven protons used to irradiate V79 cells in order to determine the feasibility of laser-driven proton therapy. A dosimetry method involving GafChromic films and numerical simulations has been appositely developed and used to obtain cell survival results, which are in agreement with those obtained by conventionally accelerated proton beams. Another part is dedicated to the detection and characterisation of laser-driven electron and X-ray beams. An innovative simulation method to obtain the temperature of the electrons accelerated by the laser, and predict the
subsequently generated X-ray beam, has been developed and compared with the acquired experimental data.

Type of Work:Ph.D. thesis.
Supervisor(s):Green, Stuart
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Physics and Astronomy
Subjects:QC Physics
Institution:University of Birmingham
ID Code:3371
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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