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Systematic investigations of calcium phosphates produced by wet chemistry method and supercritical processing techniques

Ahmad Salimi, Midhat Nabil (2013)
Ph.D. thesis, University of Birmingham.

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Abstract

Calcium phosphate (CaP) based material, especially hydroxyapatite (HAp) nanoparticles have a wide range of applications in a number of fields, such as drug delivery, gene therapy, bone cements, dental applications, chromatography and waste water remediation. Depending on the application, there is often a need for the nanoparticles to be in a particular size range. One of the potential applications of HAp is for drug delivery; as a transfection vector in specific. The main aim of this study was to evaluate the potential of various produced CaP nanoparticles for this matter. The HAp and CaP nanoparticles in this study were systematically investigated and produced by several methods, firstly by the wet chemistry method of sol-gel, where the process conditions of varying its stirring rates and temperatures were taken into consideration; secondly by the supercritical fluid techniques of Gas Anti-Solvent (GAS) and Solution Enhanced Dispersion of Supercritical Fluids (SEDS), where the process conditions of varying the processing temperature, pressure and supply of antisolvent flowrate were investigated. Lastly, several phases of CaPs were produced by a systematic investigation of CaP precipitation processes (via direct precipitation method and SEDS processing technique) by varying the Ca/P ratios. The processing conditions such as the stirring rate, temperature, pressure and antisolvent flowrate played a significant role on the nanoparticle size and morphology.

Type of Work:Ph.D. thesis.
Supervisor(s):Leeke, Gary and Grover, Liam and Bridson, Rachel H
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Subjects:TP Chemical technology
Institution:University of Birmingham
ID Code:3326
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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