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Neural cardiovascular control during exercise: influence of sex and ovarian hormones

Hartwich, Doreen (2012)
Ph.D. thesis, University of Birmingham.

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Cardiovascular control during exercise results from three main mechanisms, namely central command (descending neural input), skeletal muscle afferent feedback (metabo - and mechanoreflex) and the arterial baroreflex. The studies outlined in this thesis sought to examine the potential sex- and ovarian hormone influences in neural cardiovascular control during exercise. It was observed that the activation of metabolically sensitive skeletal muscle afferents (i.e. muscle metaboreflex) by partial restriction of blood flow to the exercising skeletal muscle contributes to the exercise tachycardia via a reduction in cardiac baroreflex sensitivity from rest during dynamic exercise. Importantly, the magnitude of this metaboreflex-mediated reduction in cardiac baroreflex responsiveness was not different between men and women during the early and late follicular phases of the ovarian cycle. Baroreflex perturbation during dynamic exercise, by means of hypotensive and hypertensive stimuli to the carotid baroreceptors, revealed that baroreflex control of blood pressure was similarly maintained during exercise in men and women. Finally it was demonstrated that the sympathetic vasoconstriction in the exercising limb is similarly blunted in men and women. Overall, the results of this thesis suggest that there are no differences between men and women in baroreflex function and sympathetic vascular responsiveness during dynamic exercise.

Type of Work:Ph.D. thesis.
Supervisor(s):Fisher, James P
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:GV Recreation Leisure
QP Physiology
Institution:University of Birmingham
ID Code:3218
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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