Mason, Helen (2011)
Ph.D. thesis, University of Birmingham.
53BP1 is a DNA damage responsive protein that plays a crucial role in checkpoint activation and DNA repair. In addition to its involvement in the cellular response to DNA damage, it has been suggested that 53BP1 can also function to regulate gene expression. 53BP1 was originally identified in a yeast two-hybrid screen for novel modulators of p53 transcriptional activity. Despite this, the role of 53BP1 in transcriptional regulation remains poorly understood.
|Type of Work:||Ph.D. thesis.|
|Supervisor(s):||Taylor, Malcolm and Stewart, Grant|
|School/Faculty:||Colleges (2008 onwards) > College of Medical & Dental Sciences|
|Department:||School of Cancer Studies|
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Institution:||University of Birmingham|
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