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Determinants of prostate cancer: the Birmingham Prostatic Neoplasms Association study

Khan, Humera (2011)
Ph.D. thesis, University of Birmingham.

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Abstract

This Birmingham Prostatic Neoplasms Association Study (BiPAS) was initiated to investigate determinants of prostate cancer. The study recruited 314 prostate cancer patients, 381 active surveillance patients, 201 hospital controls and 175 population controls. By comparing groups
of varying risk, the aetiology of the disease was investigated.

Within the BiPAS dataset, sun exposure, physical activity and obesity were analysed. The association with occupation was assessed by performing a meta analysis of 7, 762 cases and 20, 634 controls. Finally, a replication study on genetic polymorphisms on 8q24 using 277 cases and 282 controls from the Netherlands Cohort Study (NLCS) is presented.

A protective effect was observed for high sun exposure in early adulthood and high intensity exercise. An increased risk was observed for low intensity exercise and men classed as obese at age 20. The meta analysis suggested moderately increased and decreased risks associated with a number of job titles, however none were statistically significant. The results for allele A on the single nucleotide polymorphism rs1447295 were replicated; however a decreased risk was detected for allele -8 on the microsatellite DG8S737. No significant difference was detected for analysis comparing prostate cancer or high PSA cases.

Type of Work:Ph.D. thesis.
Supervisor(s):Arrand, John and Zeegers, Maurice
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Health & Population Sciences
Subjects:RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Institution:University of Birmingham
ID Code:3170
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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