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The dietary management of phenylketonuria

MacDonald, Anita (1999)
Ph.D. thesis, University of Birmingham.

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A wider understanding of the impact of each of the dietary components on blood phenylalanine concentrations in PKU may lead to improvements in management. Knowledge of the effects of such rigorous diet therapy on feeding behaviour is also important. In a series of studies, the effect of a number of dietary factors on plasma phenylalanine control and of diet on feeding behaviour was systematically investigated. The key findings were: 1) there is wide variability in plasma phenylalanine concentrations which were not reflected in a single early morning phenylalanine measurement; 2) plasma phenylalanine concentrations were more influenced by the timing and dosage of protein substitute than by total energy or excess natural protein intake from ‘freely’ allowed foods; 3) repeated 4 hourly administration of protein substitute throughout 24-hours markedly reduced phenylalanine variability and led to lower phenylalanine concentrations; 4) ‘free’ use of fruits and vegetables containing phenylalanine between 51-100 mg/100g did not adversely affect plasma phenylalanine control; and 5) feeding problems were common, with almost 50% of young children with PKU exhibiting at least 3 feeding problems. These findings in PKU are important in the understanding of feeding behaviour; the interpretation of plasma phenylalanine concentrations; they increase and rationalise the range of ‘free’ foods; and will reduce 24-hour plasma phenylalanine variability, and thus, possibly increase dietary phenylalanine tolerance.

Type of Work:Ph.D. thesis.
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:Department of Reproductive and Child Health
Subjects:RC Internal medicine
RJ Pediatrics
Institution:University of Birmingham
Library Catalogue:Check for printed version of this thesis
ID Code:29
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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