Chakupurakal, Geothy (2011)
Ph.D. thesis, University of Birmingham.
Allogeneic stem cell transplantation (SCT) is the only curative treatment option for many haematological malignancies. Adenovirus (Ad) infections are a significant cause of morbidity and mortality post SCT. Lack of effective anti-viral treatment for Ad disease has led to the development of adoptive immunotherapy of Ad-specific T-cells as a promising therapeutic option for patients in this setting. The aim of this project was to establish preclinical criteria for the development of a clinical trial comparing two T-cell enrichment methods- multimer selection and cytokine secretion selection to enrich Ad-specific T-cells for the purposes of adoptive transfer directly without the need for in vitro culture.
|Type of Work:||Ph.D. thesis.|
|Supervisor(s):||Moss, Paul A. and Mautner, Vivien|
|School/Faculty:||Colleges (2008 onwards) > College of Medical & Dental Sciences|
|Department:||School of Cancer Sciences|
The paper in Appendix II is available at http://eprints.bham.ac.uk/630/
|Subjects:||R Medicine (General)|
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Institution:||University of Birmingham|
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