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Radiation dosimetry of conventional and laser-driven particle beams

Kirby, Daniel James (2011)
Ph.D. thesis, University of Birmingham.

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Abstract

The measurement of radiation dose in radiotherapy is vital in ensuring the accuracy of treatments. As more advanced techniques using protons and ions emerge, they pose challenges to ensure the same level of accuracy of dosimetry is achieved as for conventional X-ray radiotherapy. A relatively new method of particle acceleration using ultra-high intensity lasers and thin metallic targets has sparked a large effort to investigate the possible application of this technology in radiotherapy, which in turn requires accurate methods of dosimetry to be carried out and is the main motivation for this work. Accurate dosimetry was initially performed here using an air ionisation chamber, various models of GafChromic film and a PMMA phantom in 15 and 29 MeV protons and 38 MeV \(\alpha\)-particles from the Birmingham cyclotron. In developing an accurate protocol for absorbed dose-to-water at these relatively low proton energies, new data was generated on the proton energy response of GafChromic films. This enabled accurate dosimetry of a prototype laser-particle source, and provided improvements to a method of spectroscopic measurement in the resultant mixed field of multi-energy protons, electrons and X-rays. Monte Carlo simulations using MCNPX but mainly FLUKA were performed throughout to support and verify experimental measurements.

Type of Work:Ph.D. thesis.
Supervisor(s):Green, Stuart
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Physics and Astronomy, Medical Physics
Additional Information:

The published papers in Appendix I are

Daniel Kirby et al,
LET dependence of GafChromic films and an ion chamber in low-energy proton dosimetry
2010 417 Physics in Medicine and Biology 55(2) ISSN: 0031-9155
http://stacks.iop.org/0031-9155/55/i=2/a=006

D. Kirby, Green S., Fiorini F., Parker D., Romagnani L., Doria D., Kar S., Lewis C., Borghesi M., Palmans H.,
Radiochromic film spectroscopy of laser-accelerated proton beams using the FLUKA code and dosimetry traceable to primary standards
Laser and Particle Beams 2011 Vol 29 p 231
DOI: 10.1017/S0263034611000206
http://dx.doi.org/10.1017/S0263034611000206

Keywords:radiotherapy, radiation, dosimetry, protons, ions, particles
Subjects:QC Physics
R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Daniel James Kirby
ID Code:2816
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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