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First step in the design and realisation of a 'smart' switchable surface

Pranzetti, Alice (2011)
M.Res. thesis, University of Birmingham.

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This thesis reports the first step in the design and fabrication of a double armed switchable surface that exhibits dynamic changes in its interfacial properties in terms of bio-recognition, in response to an electrical potential (Figure 1a). The aim of the work herein is to develop a suitable synthetic strategy to ensure the stability of the desired self-assembled monolayer (Figure 1b). In order to obtain a better understanding of the possible chemical interactions involved, different portions of the surface have been studied separately on a simpler system (Figure 1c). Figure 1 a) Cartoon image showing the opening of the positively charged double armed system when a negative voltage is applied and consequent interaction between biotin and streptavidin, b) chemical structure of the double armed switchable surface, c) scheme and chemical structure of the selected portions examined in the present research. In particular, this thesis will discuss the successful coupling of biotin (Figure 1c) with a 4-hydroxybenzaldehyde derivative and the attempts to obtain a ‘double armed’ 3,5-dihydroxybenzaldehyde derivative (Figure 1c) via a Huisgen reaction. The last section of this work will focus on the fabrication and characterisation of pure and mixed aromatic monolayers of 4-aminothiophenol and 4-methylbenzenethiol.

Type of Work:M.Res. thesis.
Supervisor(s):Mendes, Paula and Preece, Jon Andrew
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemistry
Subjects:QD Chemistry
Institution:University of Birmingham
ID Code:1587
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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