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The effect of Staphylococcus epidermidis on the pH and dissolution of substitute bone graft materials

McAvinchey, Sinead Anne (2011)
M.Phil. thesis, University of Birmingham.

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The objective of this study was to determine the effect of S. epidermidis 11047 on the pH and dissolution of 5 different bone substitute materials. Part 1 – Measured the pH, calcium and phosphate of the culture medium in the presence and absence of the 5 bone substitute materials before and after autoclaving. Part 2 – Measured the pH of the culture medium in the presence and absence of the 5 bone substitute materials before autoclaving and measurement of pH, calcium and phosphate 24 hrs later following incubation in the presence or absence of S. epidermidis. In part 1 it was concluded that autoclaving does not have a clinically significant effect on pH, calcium or phosphate levels of a culture medium in the presence or absence of the 5 bone substitute materials for the purposes of this study. There was a statistically significant reduction in pH, with a maximum decrease of 0.09. In part 2 it was concluded that there was a statistically and potentially clinically significant reduction in pH caused by the presence of S. epidermidis in all test samples and Cerasorb M (H4) is degraded in the presence of S. epidermidis.

Type of Work:M.Phil. thesis.
Supervisor(s):Sammons, Rachel L.
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Biomaterials Unit, School of Dentistry
Subjects:RK Dentistry
Institution:University of Birmingham
ID Code:1586
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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