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Development and characterisation of a Portland cement-based dental root filling material

O'Beirne, Joanne L. (2011)
Ph.D. thesis, University of Birmingham.

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Mineral trioxide aggregate (MTA) is a Portland cement (PC)-based endodontic material used for sealing root canals. This study investigated the effect of calcium sulphate additions for improving the undesirably-long setting time of MTA-like dental materials, whilst maintaining the mechanical, biological and sealing properties. 10wt%PoP accelerated initial setting times of grey and white model cements and MTA from >6h to <40min, and did not significantly change compressive strengths and relative porosities with long-term storage in media. Cement pastes containing PoP may „false‟ set or stiffen through gypsum precipitation, seen in scanning electron photomicrographs of MTA-like cements with 30wt%PoP. Similar in vitro responses of adult and neonatal BMSC, periosteal and osteoblastic cultures were noted with PoP-modified and unmodified cements. Inhibition of cell growth was seen with 3day-cultures containing modified model cements and MTA, the possible result of calcium hydroxide release from cements. Sealing properties were characterised using dye leakage studies and concluded that the sealing abilities of model cements and MTA were not compromised by PoP addition. In summary, 10wt%PoP has shown potential as a modification to MTA by reducing the setting time whilst maintaining mechanical stability, solubility, in vitro responses to and the sealing properties of MTA, therefore, warrants further investigation.

Type of Work:Ph.D. thesis.
Supervisor(s):Hofmann, Michael P. and Shelton, Richard M. and Lumley, Phillip J.
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Dentistry, Biomaterials Unit
Subjects:Q Science (General)
T Technology (General)
RK Dentistry
R Medicine (General)
Institution:University of Birmingham
ID Code:1528
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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