eTheses Repository

Development and validation of the BILAG-2004 Index for the assessment of disease activity in systemic lupus erythematosus

Yee, Chee Seng (2008)
Ph.D. thesis, University of Birmingham.

Loading
PDF (1632Kb)

Abstract

This research to develop and validate the BILAG-2004 index for the assessment of disease activity in patients with [systemic lupus erythematosus] SLE had involved several validation studies. The reliability of this index was shown in 2 exercises, as assessed by level of agreement, kappa statistic, ICC and disagreement between physicians. This study also highlighted the importance of training in ensuring optimal performance of the index. This index had construct validity as higher scores in the index were significantly associated increasing ESR, decreasing C3, decreasing C4, elevated anti-dsDNA antibody and increasing SLEDAI-2000 scores. Active disease scores were significantly associated with increase in therapy, confirming the criterion validity of the index. Sensitivity to change was demonstrated as changes in the score of the index were differentially related to change in therapy, with greater change in score having greater predictive power. Rasch analysis showed that this index had a good fit to the Rasch model, indicating that it is a unidimensional ordinal scale index with internal construct validity. The validation studies led to revisions of the index to ensure it had face and content validity. The results of this research have shown that the revised BILAG-2004 index is valid for use to assess SLE disease activity.

Type of Work:Ph.D. thesis.
Supervisor(s):Gordon, Caroline
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:Division of Infection and Immunology, Rheumatology Research Group
Keywords:Systemic Lupus Erythematosus, Disease Activity, Outcome Measure, BILAG, SLEDAI, Validation
Subjects:RC Internal medicine
Institution:University of Birmingham
Library Catalogue:Check for printed version of this thesis
ID Code:149
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
Export Reference As : ASCII + BibTeX + Dublin Core + EndNote + HTML + METS + MODS + OpenURL Object + Reference Manager + Refer + RefWorks
Share this item :
QR Code for this page

Repository Staff Only: item control page