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Improving the identification of a penicillin fermentation model

Syddall, Mark Timothy (1999)
Ph.D. thesis, University of Birmingham.

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Abstract

This work concentrates on the selection and improvement of differential equation based models of the penicillin G fermentation. Published penicillin fermentation models have been reviewed and compared with regard to their abilities to predict fermentation behaviour, genetic algorithms have been applied to the design of optimal experiments for model parameter estimation, and a new approach to assessing the theoretical identifiability of model structures has been proposed. When applied to the best penicillin fermentation model yet found, this new approach suggests that the model's parameters are uniquely identifiable. The best performing model was shown to be a morphologically structured model for which measurement data related to the various morphologically distinct regions were obtained using image analysis. This model was modified to increase its speed of execution, and extended to describe fermentations where lactose was present in the inoculum. Design criteria from the field of optimal experiment design were combined with genetic algorithms as a technique for searching through the range of possible input combinations, subject to constraints on the fermenter operation, to develop experimental feed profiles. The theoretical identifiability of the fermentation model has been assessed for the first time, using a novel approach to identifiability testing which uses a symbolic mathematics package, along with subsequent post-processing, to determine almost at a glance whether or not a fermentation model should be uniquely identifiable.

Type of Work:Ph.D. thesis.
Supervisor(s):Kent, C. A. and Thomas, C. R. (Colin R.)
School/Faculty:Schools (1998 to 2008) > School of Engineering
Department:School of Chemical Engineering
Subjects:TP Chemical technology
Institution:University of Birmingham
Library Catalogue:Check for printed version of this thesis
ID Code:1478
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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