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Oxidative stress biomarkers in dementia

Bennett, Stuart James (2011)
Ph.D. thesis, University of Birmingham.

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Abstract

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which is thought to affect 26.6 million individuals worldwide. There is growing concern over a worldwide dementia epidemic that is predicted to develop over the coming decades. The evidence thus far suggests that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. The thesis aimed to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated using both hypothesis driven and proteomic approaches. Results presented in this thesis suggest that global plasma protein oxidation levels are not different when AD and control subjects are compared, but that individual plasma proteins are specific targets for oxidative modification in AD. The thesis explores different methodologies to assess oxidative changes in AD. In addition it demonstrates that emerging novel and powerful mass spectrometry techniques can be employed successfully to identify several proteins modified by oxidation, providing an initial starting point for further investigation.

Type of Work:Ph.D. thesis.
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Additional Information:

Research from this thesis is published in: Bennett,S., Grant,M.M., and Aldred,S. (2009). Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology. J. Alzheimers Dis. Jun; 17(2):245-57. DOI: 10.3233/JAD-2009-1041 Aldred,S., Bennett,S., and Mecocci,P. (2010). Increased low density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clin. Biochem. Feb;43(3):267-71.

Subjects:RC1200 Sports Medicine
RA0421 Public health. Hygiene. Preventive Medicine
Institution:University of Birmingham
ID Code:1449
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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