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Correlation of tumour volume of childhood posterior fossa tumours with outcome

Kombogiorgas, Dimitrios (2010)
M.Phil. thesis, University of Birmingham.

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Abstract

Aim: To study if the amount of residual medulloblastoma correlates with improved survival. Material and Methods: Tumour volumes were measured on preoperative and immediate postoperative MR scans of 37 children operated on for medulloblastoma between 1999 and 2006. The residuum ratio (post-/ preoperative tumour volume) was calculated and correlated to mortality and actuarial survival. Results: Mean preoperative volume was 32 cm³ (range: 4.43-71.99 cm³). Mean postoperative volume was 3.3 cm³ (range: 0- 23.3 cm³). Mean residuum ratio was 10.7% (range: 0-74%); 28 (75.7%) patients had ≤15% residuum. At mean follow-up of 45 months (range: 6-117), 15 (40.5%) patients had died. Using either the presence of any residual tumour or a limit of 15% residuum ratio, there was no statistically significant difference in mortality or actuarial 5-year survival (p: 0.27, log rank). Also, the difference in 5-year survival of patients with a residual tumour > and >1.5 cm³ was not statistically significant (p= 0.367). Conclusions: While there is a trend for patients with less residual medulloblastoma volume to have better outcome than those with more residual medulloblastoma volume, the number of the patients of this pilot study was not large enough to reach a conclusion and a larger study is required.

Type of Work:M.Phil. thesis.
Supervisor(s):English, M and Sgouros, Spyridon
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Medicine
Subjects:RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Institution:University of Birmingham
ID Code:1387
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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