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The use of health economics in the early evaluation of regenerative medicine therapies

McAteer, Helen (2011)
Ph.D. thesis, University of Birmingham.

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The aim of this thesis is to help the RM industry avoid misguidedly investing in technologies that are unlikely to be cost-effective and reimbursed by healthcare providers. Health economics provides the tools to demonstrate value for money. These tools are typically used by healthcare providers to drive demand side decisions. However, they can be used by manufacturers to inform the supply side. I propose a simple approach, termed the headroom method. This ‘back of the envelope’ calculation is based on estimates of effectiveness of the proposed treatment towards the upper end of the plausible range. The method can be used either to inform an intuitive decision to continue or abandon development, or as a screening test to decide if more elaborate models are justified. One problem I encountered was the development of technologies without clearly defining the clinical problem. In particular, the marginal gain in benefit over alternative treatments is frequently overlooked. A large part of this thesis is therefore concerned with the clinical epidemiology of the conditions at which treatment is targeted. In this way, it was found, for example, the headroom for health gain from new treatment for inguinal hernia was much smaller than that for incisional hernias.

Type of Work:Ph.D. thesis.
Supervisor(s):Lilford, Richard J. and Frew, Emma
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Public Health, Epidemiology and Biostatistics Unit, School of Health and Population Sciences.
Subjects:HF Commerce
HB Economic Theory
RA Public aspects of medicine
Institution:University of Birmingham
ID Code:1357
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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