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Nanotexturisation of gold surfaces and its application to neural implants

Frommhold, Andreas (2011)
Ph.D. thesis, University of Birmingham.

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Abstract

The objective of this thesis was to develop a new methodology for the improvement of the interface properties of gold electrodes for neural implants. The goal was to increase the surface area without a change in geometrical footprint of the electrode with nano-fabrication tools. A process has been created that uses Nanosphere Lithography for masking layer deposition and anisotropic etching to fabricate nanostructures on the surface of the electrodes. Optimisation of the process parameters led to a control of structure shape, which allowed to produce a variety of shapes. The effect of the nano-structures on the interface was investigated by impedance spectroscopy and complementary electrochemical measurements. It showed that the interface impedance could be decreased significantly by up to a magnitude of scale with the surface modifications. In addition a porous columnar form of sputtered gold was found that also showed decreased interface impedance compared to standard gold films. A set of neural implants was designed and fabricated to test the effect of surface modification in vitro in neurological tissue. The surface modification process was successfully implemented in the device fabrication. The in-vitro assessment showed signs of improved interface performance compared to unmodified devices.

Type of Work:Ph.D. thesis.
Supervisor(s):Tarte, Edward
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:Department of Electrical, Electronics and Computer Engineering
Subjects:TK Electrical engineering. Electronics Nuclear engineering
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
TN Mining engineering. Metallurgy
Institution:University of Birmingham
ID Code:1330
This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder.
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